Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Ind Med. 2013 May;56(5):522-30. doi: 10.1002/ajim.22165. Epub 2013 Feb 6.

Markers of upper airway inflammation associated with microbial exposure and symptoms in occupants of a water-damaged building.

Author information

1
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.

Abstract

BACKGROUND:

Water damage in buildings has been associated with reports of upper airway inflammation among occupants.

METHODS:

This survey included a questionnaire, allergen skin testing, nasal nitric oxide, and nasal lavage on 153 participants. We conducted exposure assessments of 297 workstations and analyzed collected dust for fungi, endotoxin, and (1 → 3)-β-D-glucan to create floor-specific averages.

RESULTS:

Males had higher levels of nasal inflammatory markers, and females reported more symptoms. ECP, IL-8, and MPO were significantly associated with nasal symptoms, flu-like achiness, or chills. Fungi and glucan were positively associated with blowing out thick mucus. Endotoxin was significantly associated with ECP in overall models, and with ECP, IL-8, MPO, and neutrophils among non-atopic females.

CONCLUSIONS:

In this study, we documented an association between endotoxin and nasal inflammatory markers among office workers. The results of our study suggest that a non-allergic response may contribute to symptoms occurring among occupants in this water-damaged building.

PMID:
23390064
DOI:
10.1002/ajim.22165
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center