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Chem Commun (Camb). 2013 Mar 14;49(21):2151-3. doi: 10.1039/c3cc37795d. Epub 2013 Feb 7.

No-carrier-added [18F]fluoroarenes from the radiofluorination of diaryl sulfoxides.

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1
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3 C346A, 10 Center Drive, Bethesda, MD 20892-1003, USA.

Abstract

No-carrier-added [(18)F]fluoroarenes were synthesized through the radiofluorination of diaryl sulfoxides with [(18)F]fluoride ion. Diaryl sulfoxides bearing a para electron-withdrawing substituent readily gave the corresponding 4-[(18)F]fluoroarenes in high RCYs. This process broadens the scope for preparing novel (18)F-labeling synthons and PET radiotracers.

PMID:
23388835
PMCID:
PMC3587981
DOI:
10.1039/c3cc37795d
[Indexed for MEDLINE]
Free PMC Article
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