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Genes Dev. 2013 Feb 1;27(3):227-33. doi: 10.1101/gad.213306.113.

Four pillars of the S-phase checkpoint.

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1
Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.

Abstract

The yeast Mec1 kinase is a key regulator of the DNA damage response (DDR). In this issue of Genes & Development, Kumar and Burgers (pp. 313-321) report that Ddc1, Dpb11, and Dna2 function in concert to activate Mec1 during S phase of the cell cycle. Furthermore, the Tel1 kinase also contributes to the DDR in S phase when Mec1 activation is compromised.

PMID:
23388823
PMCID:
PMC3576509
DOI:
10.1101/gad.213306.113
[Indexed for MEDLINE]
Free PMC Article
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