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Nat Rev Cancer. 2013 Mar;13(3):201-8. doi: 10.1038/nrc3468. Epub 2013 Feb 7.

In the wrong place at the wrong time: does cyclin mislocalization drive oncogenic transformation?

Author information

1
Vernalis (R&D), Granta Park, Great Abington, Cambridge CB21 6GB, UK. j.moore@horizondiscovery.com

Abstract

Cyclin-dependent kinases (CDKs) are regulated by both cyclin abundance and cyclin localization. Increased cyclin expression in cancer was first observed two decades ago, and its role in pathogenesis has been investigated in great depth. This Opinion article focuses on the spatial deregulation of cyclin expression and its potential link to oncogenesis. It describes the contexts in which particular cyclins have been reported to be mislocalized in neoplasia, reviews the mechanisms underlying the dynamic subcellular localization of CDK-cyclin complexes in normal cells, and discusses how these controls can be disrupted in cancer. It also outlines the mechanisms by which cyclin mislocalization might disrupt cell cycle control and interfere with faithful chromosome segregation. Finally, it discusses the extent to which cyclin mislocalization might facilitate tumorigenesis in human cancer.

PMID:
23388618
DOI:
10.1038/nrc3468
[Indexed for MEDLINE]
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