Send to

Choose Destination
See comment in PubMed Commons below
Am J Surg. 2013 Jul;206(1):64-71. doi: 10.1016/j.amjsurg.2012.06.010. Epub 2013 Feb 4.

Is less than 5 mm as the narrowest surgical margin width in central resections of hepatocellular carcinoma justified?

Author information

Department of Surgery, Far Eastern Memorial Hospital, Taipei, Taiwan.



The aim of this study was to investigate whether <5 mm as the narrowest margin width may negatively affect a patient's outcome.


A prospective cohort study was designed. From January 1994 to July 2010, 196 patients with hepatocellular carcinoma undergoing central hepatectomy were divided into group A (n = 172; narrowest margin, ≥5 to <10 mm) and group B (n = 24; narrowest margin, <5 mm), and outcomes were compared.


Significant differences between groups A and B included tumor size (P = .057), infiltrative border (P = .021), satellite lesions (P = .021), and major perivascular abutment (P = .028). Marginal recurrence occurred in 50% of the patients in group B but none of those in group A (P < .001). There were no significant differences between the groups regarding recurrence, recurrence-related death, disease-free survival, and speed of recurrence, but a borderline significant difference was found regarding the cumulative probability of overall survival. After excluding early recurrence (within 1 year), group B had significantly lower cumulative probabilities of disease-free survival (P = .020) and overall survival (P < .001).


In central resections, narrowest margin width of <5 mm does not negatively affect recurrence and overall survival. However, it increases perimargin recurrence and inversely affects late outcomes.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center