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Int J Neurosci. 2013 Jul;123(7):444-9. doi: 10.3109/00207454.2013.765870. Epub 2013 Feb 19.

Revisiting choline alphoscerate profile: a new, perspective, role in dementia?

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Neuropsichiatria Geriatrica, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Roma, Italia.


Choline alphoscerate (alpha-glyceryl-phosphorylcholine, alpha-GPC) is a semisynthetic derivative of phosphatidylcholine with central parasympathomimetic action. This action is, on the basis of its use in pathologies, characterized by cognitive deficits of neurodegenerative or vascular nature. In a number of clinical studies, alpha-GPC demonstrated benefit in patients with cognitive dysfunction. In light of the limited therapeutical results obtained in the past decades by the use of cholinesterase inhibitors in dementia, and of the relevance of their side effects in long-lasting therapies, it is desirable to reconsider alpha-GPC in larger carefully controlled studies not only as monotherapy but also in association with cholinesterase inhibitor drugs.

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