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Yao Xue Xue Bao. 2012 Nov;47(11):1521-6.

[Identification of metabolites of arbidol by ultra-high performance liquid chromatography tandem mass spectrometry].

[Article in Chinese]

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1
College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China.

Abstract

UPLC-MS-MS system was used for the identification of arbidol metabolites in the rat feces, urine and plasma samples. The system was so powerful a way with high ability of separation and analysis, based on both chromatography and mass properties. The isotope of Br was also a good indicator for metabolites finding. There were altogether 9 metabolites detected and identified, including 2 phase I biotransformation products and 7 phase II ones. It is concluded that arbidol mainly undergo metabolic reactions such as N-demethylation, S-oxidation, glucuronidation and sulfation in rats.

PMID:
23387087
[Indexed for MEDLINE]
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