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Front Neurosci. 2013 Feb 5;6:197. doi: 10.3389/fnins.2012.00197. eCollection 2012.

Symmetric diffeomorphic modeling of longitudinal structural MRI.

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Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology London, UK.


This technology report describes the longitudinal registration approach that we intend to incorporate into SPM12. It essentially describes a group-wise intra-subject modeling framework, which combines diffeomorphic and rigid-body registration, incorporating a correction for the intensity inhomogeneity artifact usually seen in MRI data. Emphasis is placed on achieving internal consistency and accounting for many of the mathematical subtleties that most implementations overlook. The implementation was evaluated using examples from the OASIS Longitudinal MRI Data in Non-demented and Demented Older Adults.


diffeomorphisms; geodesic shooting; inverse consistency; longitudinal registration; non-linear registration; shape modeling; symmetry; transitivity

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