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Eur Heart J. 2013 Nov;34(44):3451-7. doi: 10.1093/eurheartj/eht007. Epub 2013 Feb 4.

Aspirin treatment hampers the use of plasma microRNA-126 as a biomarker for the progression of vascular disease.

Author information

1
Department of Nephrology and the Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

Abstract

AIMS:

MicroRNA-126 (miR-126) facilitates angiogenesis and regulates endothelial cell function. Recent data suggest that miR-126 can serve as a biomarker for vascular disease. Although endothelial cells are enriched for miR-126, platelets also contain miR-126. In this paper, we investigated the contribution of platelets to the pool of miR-126 in plasma of patients with type 2 diabetes (DM2) and how this is affected by aspirin.

METHODS AND RESULTS:

In vitro platelet activation resulted in the transfer of miR-126 from the platelet to the plasma compartment, which was prevented by aspirin. In vivo platelet activation, monitored in patients with DM2 by measuring soluble P-selectin, correlated directly with circulating levels of miR-126. The administration of aspirin resulted both in platelet inhibition and concomitantly reduced circulating levels of platelet-derived microRNAs including miR-126.

CONCLUSION:

Platelets are a major source of circulating miR-126. Consequently, in patho-physiological conditions associated with platelet activation, such as diabetes type 2, the administration of aspirin may lead to reduced levels of circulating miR-126. Thus, the use of platelet inhibitors should be taken into account when using plasma levels of miR-126 as a biomarker.

KEYWORDS:

aspirin; diabetes mellitus type 2; miR-126; platelets

PMID:
23386708
DOI:
10.1093/eurheartj/eht007
[Indexed for MEDLINE]
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