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Methods Mol Biol. 2013;984:263-73. doi: 10.1007/978-1-62703-296-4_19.

Evaluating amyloid Beta (aβ) 1-40 degradation by capillary electrophoresis.

Author information

1
Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN, USA.

Abstract

Here, we describe a capillary electrophoresis method for evaluating proteolysis of the amyloid beta peptide (Aβ) 1-40. This method is suitable for kinetic studies, demands little specialized equipment, and consumes only small quantities of a commercially available substrate whose physiological accumulation is thought to underlie the development of Alzheimer's disease.

PMID:
23386350
DOI:
10.1007/978-1-62703-296-4_19
[Indexed for MEDLINE]

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