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Nat Rev Neurosci. 2013 Mar;14(3):202-16. doi: 10.1038/nrn3444. Epub 2013 Feb 6.

New insights into the classification and nomenclature of cortical GABAergic interneurons.

Author information

1
Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Campus Montegancedo S/N, Pozuelo de Alarcón, 28223 Madrid, Spain. defelipe@cajal.csic.es

Abstract

A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxonomical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web-based interactive system that allows experts to classify neurons with pre-determined criteria. Using Bayesian analysis and clustering algorithms on the resulting data, we investigated the suitability of several anatomical terms and neuron names for cortical GABAergic interneurons. Moreover, we show that supervised classification models could automatically categorize interneurons in agreement with experts' assignments. These results demonstrate a practical and objective approach to the naming, characterization and classification of neurons based on community consensus.

PMID:
23385869
PMCID:
PMC3619199
DOI:
10.1038/nrn3444
[Indexed for MEDLINE]
Free PMC Article

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