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Bioorg Med Chem Lett. 2013 Mar 1;23(5):1197-200. doi: 10.1016/j.bmcl.2013.01.028. Epub 2013 Jan 16.

Identification of acidic heterocycle-substituted 1H-pyrazolo[3,4-b]pyridines as soluble guanylate cyclase stimulators.

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1
Bayer Pharma AG, Global Drug Discovery, Medicinal Chemistry Wuppertal, D-42096 Wuppertal, Germany. nils.griebenow@bayer.com

Abstract

Novel guanylate cyclase stimulators are disclosed. Design, synthesis, SAR, and pharmacological profile of the compounds are discussed.

PMID:
23385209
DOI:
10.1016/j.bmcl.2013.01.028
[Indexed for MEDLINE]
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