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Curr Opin Cell Biol. 2013 Apr;25(2):170-6. doi: 10.1016/j.ceb.2013.01.003. Epub 2013 Feb 4.

The circadian epigenome: how metabolism talks to chromatin remodeling.

Author information

1
Center for Epigenetics and Metabolism, Unité 904 Institut National de la Santé et de la Recherche Médicale (INSERM).

Abstract

Circadian rhythms occur in most of the living organisms, and with a 24 hour periodicity govern a number of physiological and metabolic functions. During the past few years, an important research effort has uncovered new trails that intersect between circadian rhythms and metabolic pathways. At a molecular level, the clock machinery is responsible for the establishment of a circadian epigenome, and this can be modulated by metabolic cues. Indeed, metabolic control by the circadian clock is manifest in the development of metabolic diseases when circadian rhythms are impaired. Thus, pharmacological modulation of circadian rhythms promises new avenues for the treatment of metabolic and sleep disorders.

PMID:
23385084
PMCID:
PMC4573393
DOI:
10.1016/j.ceb.2013.01.003
[Indexed for MEDLINE]
Free PMC Article

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