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Curr Opin Immunol. 2013 Apr;25(2):168-73. doi: 10.1016/j.coi.2013.01.002. Epub 2013 Feb 4.

Natural Killer T cell obsession with self-antigens.

Author information

1
Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, CO 80206, USA. gapinl@njhealth.org

Abstract

Natural Killer T (NKT) cells are distinct lymphocyte lineages that recognize lipid antigens presented by the non-classical Major Histocompatibility Complex molecule CD1d. Two categories of NKT cells, type I and type II, have been described based on T-cell receptor expression and antigenic specificity. In both cases, increasing evidence suggest that recognition of self-antigens by these cells plays an important role not only in their development but also in their regulation of a broad range of immune responses. Here we review recent advances in our understanding of how and when NKT cell autoreactivity manifests itself, how the NKT T cell receptor engages self-antigens and the nature of these self-antigens.

PMID:
23384972
PMCID:
PMC3646945
DOI:
10.1016/j.coi.2013.01.002
[Indexed for MEDLINE]
Free PMC Article

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