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Br J Haematol. 2013 Apr;161(1):3-14. doi: 10.1111/bjh.12235. Epub 2013 Feb 6.

Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management.

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1
Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53226-3548, US. Julie.Peterson@bcw.edu

Abstract

Neonatal alloimmune thrombocytopenia, (NAIT) is caused by maternal antibodies raised against alloantigens carried on fetal platelets. Although many cases are mild, NAIT is a significant cause of morbidity and mortality in newborns and is the most common cause of intracranial haemorrhage in full-term infants. In this report, we review the pathogenesis, clinical presentation, laboratory diagnosis and prenatal and post-natal management of NAIT and highlight areas of controversy that deserve the attention of clinical and laboratory investigators.

PMID:
23384054
PMCID:
PMC3895911
DOI:
10.1111/bjh.12235
[Indexed for MEDLINE]
Free PMC Article
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