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Phys Rev Lett. 2013 Jan 4;110(1):018103. Epub 2013 Jan 3.

Stress-enhanced gelation: a dynamic nonlinearity of elasticity.

Author information

1
Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA.

Abstract

A hallmark of biopolymer networks is their sensitivity to stress, reflected by pronounced nonlinear elastic stiffening. Here, we demonstrate a distinct dynamical nonlinearity in biopolymer networks consisting of filamentous actin cross-linked by α-actinin-4. Applied stress delays the onset of relaxation and flow, markedly enhancing gelation and extending the regime of solidlike behavior to much lower frequencies. We show that this macroscopic network response can be accounted for at the single molecule level by the increased binding affinity of the cross-linker under load, characteristic of catch-bond-like behavior.

PMID:
23383843
PMCID:
PMC3683845
DOI:
10.1103/PhysRevLett.110.018103
[Indexed for MEDLINE]
Free PMC Article

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