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Afr Health Sci. 2012 Sep;12(3):331-3.

Profound reduction of CD4+ lymphocytes without HIV infection: two cases from the horn of Africa.

Author information

1
Catalan Association for the Control of Tuberculosis in the Third World (ACTMON), Barcelona, Spain. olleuganda@gmail.com

Abstract

Idiopathic CD4+ lymphocytopenia is a disorder associated with low CD4+ T cell count and opportunistic infections resembling AIDS. Most cases are described in developed countries. We report two HIV-negative patients with idiopathic CD4+ lymphocytopenia and AIDS-defining events diagnosed in Djibouti. The first patient developed lesions of Kaposi's sarcoma and the second one presented with pulmonary tuberculosis. Both patients died with severe immunodepression. In poor resource-areas where HIV testing may not be available it is important to bear in mind that severe immunodepression and a clinical presentation compatible with AIDS do not necessary carry the diagnosis of AIDS.

KEYWORDS:

Acquired immunodeficiency syndrome; Djibouti; Human immunodeficiency virus; Kaposi's sarcoma; Lymphopenia; tuberculosis

PMID:
23382748
PMCID:
PMC3557673
[Indexed for MEDLINE]
Free PMC Article
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