Polyomavirus-associated nephritis in 2 horses

Vet Pathol. 2013 Sep;50(5):769-74. doi: 10.1177/0300985813476063. Epub 2013 Feb 4.

Abstract

Polyomaviruses produce latent and asymptomatic infections in many species, but productive and lytic infections are rare. In immunocompromised humans, polyomaviruses can cause tubulointerstitial nephritis, demyelination, or meningoencephalitis in the central nervous system and interstitial pneumonia. This report describes 2 Standardbred horses with tubular necrosis and tubulointerstitial nephritis associated with productive equine polyomavirus infection that resembles BK polyomavirus nephropathy in immunocompromised humans.

Keywords: horse; kidney; myocarditis; nephritis; polyomavirus.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Blood Chemical Analysis / veterinary
  • Capsid Proteins / genetics
  • DNA Primers / genetics
  • Fatal Outcome
  • Female
  • Horse Diseases / immunology
  • Horse Diseases / pathology*
  • Horse Diseases / virology*
  • Horses
  • Immunocompromised Host / immunology*
  • Immunoglobulin G / blood
  • Immunohistochemistry / veterinary
  • Kidney Cortex Necrosis / pathology
  • Kidney Cortex Necrosis / veterinary*
  • Kidney Cortex Necrosis / virology
  • Male
  • Nephritis, Interstitial / pathology
  • Nephritis, Interstitial / veterinary*
  • Nephritis, Interstitial / virology
  • Phylogeny
  • Polyomavirus / genetics*
  • Polyomavirus Infections / pathology
  • Polyomavirus Infections / veterinary*

Substances

  • Capsid Proteins
  • DNA Primers
  • Immunoglobulin G
  • VP1 protein, polyomavirus