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Molecules. 2013 Feb 4;18(2):1963-72. doi: 10.3390/molecules18021963.

Biohybrid -Se-S- coupling reactions of an amino acid derived seleninate.

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1
Department of Chemistry & Chemical Biology, Rutgers, the State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA.

Abstract

We describe the synthesis of the N-(2-seleninatoethyl) amide of N-Boc-phenylalanine, serving here as a peptide model, and its reductive coupling reactions under mild conditions with unprotected thiouridine and glutathione. Selenosulfide products such as these comprise reversibly conjugated bio-components, and can potentially find uses as probes of biological function, such as enzyme inhibitors, delivery systems, or structural mimics.

PMID:
23381022
DOI:
10.3390/molecules18021963
[Indexed for MEDLINE]
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