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Sci Rep. 2013;3:1188. doi: 10.1038/srep01188. Epub 2013 Feb 1.

Circulating human basophils lack the features of professional antigen presenting cells.

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Unité 872, Institut National de la Santé et de la Recherche Médicale, Paris, F-75006, France.

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  • Sci Rep. 2013 Aug. doi: 10.1038/srep01188. Maddur, Mohan S [added].


Recent reports in mice demonstrate that basophils function as antigen presenting cells (APC). They express MHC class II and co-stimulatory molecules CD80 and CD86, capture and present soluble antigens or IgE-antigen complexes and polarize Th2 responses. Therefore, we explored whether human circulating basophils possess the features of professional APC. We found that unlike dendritic cells (DC) and monocytes, steady-state circulating human basophils did not express HLA-DR and co-stimulatory molecules CD80 and CD86. Basophils remained negative for these molecules following stimulation with soluble Asp f 1, one of the allergens of Aspergillus fumigatus; Bet v 1, the major birch allergen; TLR2-ligand or even upon IgE cross-linking. Unlike DC, Asp f 1-pulsed basophils did not promote Th2 responses as analyzed by the secretion of IL-4 in the basophil-CD4(+) T cell co-culture. Together, these results demonstrate the inability of circulating human basophils to function as professional APC.

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