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J Leukoc Biol. 2013 Oct;94(4):613-22. doi: 10.1189/jlb.1112600. Epub 2013 Feb 1.

Regulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectors.

Author information

  • 11.The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA 92037, USA. scatz@scripps.edu; Twitter: http://www.scripps.edu/catz/

Abstract

The Rab27 family of GTPases regulates the efficiency and specificity of exocytosis in hematopoietic cells, including neutrophils, CTLs, NK cells, and mast cells. However, the mechanisms regulated by Rab27 GTPases are cell-specific, as they depend on the differential expression and function of particular effector molecules that are recruited by the GTPases. In addition, Rab27 GTPases participate in multiple steps of the regulation of the secretory process, including priming, tethering, docking, and fusion through sequential interaction with multiple effector molecules. Finally, recent reports suggest that Rab27 GTPases and their effectors regulate vesicular trafficking mechanisms other than exocytosis, including endocytosis and phagocytosis. This review focuses on the latest discoveries on the function of Rab27 GTPases and their effectors Munc13-4 and Slp1 in neutrophil function comparatively to their functions in other leukocytes.

KEYWORDS:

Munc13-4; exocytosis, phagocytosis; inflammation; innate immunity; synaptotagmin-like protein

PMID:
23378593
PMCID:
PMC3774847
DOI:
10.1189/jlb.1112600
[PubMed - indexed for MEDLINE]
Free PMC Article
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