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Br J Psychiatry. 2013 Feb;202:100-7. doi: 10.1192/bjp.bp.111.106666.

Vitamin D deficiency and depression in adults: systematic review and meta-analysis.

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  • 1Department of Psychiatry and Behavioural Neurosciences, St Joseph's Hospital, 50 Charlton Avenue E, Hamilton, Ontario, Canada. anglinr@mcmaster.ca

Abstract

BACKGROUND:

There is conflicting evidence about the relationship between vitamin D deficiency and depression, and a systematic assessment of the literature has not been available.

AIMS:

To determine the relationship, if any, between vitamin D deficiency and depression.

METHOD:

A systematic review and meta-analysis of observational studies and randomised controlled trials was conducted.

RESULTS:

One case-control study, ten cross-sectional studies and three cohort studies with a total of 31 424 participants were analysed. Lower vitamin D levels were found in people with depression compared with controls (SMD = 0.60, 95% CI 0.23-0.97) and there was an increased odds ratio of depression for the lowest v. highest vitamin D categories in the cross-sectional studies (OR = 1.31, 95% CI 1.0-1.71). The cohort studies showed a significantly increased hazard ratio of depression for the lowest v. highest vitamin D categories (HR = 2.21, 95% CI 1.40-3.49).

CONCLUSIONS:

Our analyses are consistent with the hypothesis that low vitamin D concentration is associated with depression, and highlight the need for randomised controlled trials of vitamin D for the prevention and treatment of depression to determine whether this association is causal.

PMID:
23377209
DOI:
10.1192/bjp.bp.111.106666
[PubMed - indexed for MEDLINE]
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