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Br J Psychiatry. 2013 Feb;202:91-3. doi: 10.1192/bjp.bp.112.110999.

When the drugs don't work: the potential of glutamatergic antipsychotics in schizophrenia.

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1
Institute of Psychiatry, King's College London, Department of Psychosis Studies, De Crespigny Park, Denmark Hill, London, UK. evangelos.papanastasiou@kcl.ac.uk

Abstract

Currently available antipsychotic drugs target dopaminergic neurotransmission. Many patients do not respond fully to these treatments, and there has been considerable effort to investigate alternative targets. Here we summarise the rationale and recent evidence supporting efforts to develop glutamatergic antipsychotic drugs.

PMID:
23377207
DOI:
10.1192/bjp.bp.112.110999
[Indexed for MEDLINE]
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