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Nat Immunol. 2013 Mar;14(3):290-7. doi: 10.1038/ni.2527. Epub 2013 Feb 3.

Mcl-1 is essential for the survival of plasma cells.

Author information

1
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

Erratum in

  • Nat Immunol. 2013 Aug;14(8):877.

Abstract

The long-term survival of plasma cells is entirely dependent on signals derived from their environment. These extrinsic factors presumably induce and sustain the expression of antiapoptotic proteins of the Bcl-2 family. It is uncertain whether there is specificity among Bcl-2 family members in the survival of plasma cells and whether their expression is linked to specific extrinsic factors. We found here that deletion of the gene encoding the antiapoptotic protein Mcl-1 in plasma cells resulted in rapid depletion of this population in vivo. Furthermore, we found that the receptor BCMA was needed to establish high expression of Mcl-1 in bone marrow but not spleen plasma cells and that establishing this survival pathway preceded the component of plasma cell differentiation that depends on the transcriptional repressor Blimp-1. Our results identify a critical role for Mcl-1 in the maintenance of plasma cells.

Comment in

PMID:
23377201
PMCID:
PMC4041127
DOI:
10.1038/ni.2527
[Indexed for MEDLINE]
Free PMC Article

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