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Nat Neurosci. 2013 Mar;16(3):270-2. doi: 10.1038/nn.3323. Epub 2013 Feb 3.

Fear and panic in humans with bilateral amygdala damage.

Author information

1
Department of Neurology, University of Iowa, Iowa City, Iowa, USA.

Abstract

Decades of research have highlighted the amygdala's influential role in fear. We found that inhalation of 35% CO(2) evoked not only fear, but also panic attacks, in three rare patients with bilateral amygdala damage. These results indicate that the amygdala is not required for fear and panic, and make an important distinction between fear triggered by external threats from the environment versus fear triggered internally by CO(2).

PMID:
23377128
PMCID:
PMC3739474
DOI:
10.1038/nn.3323
[Indexed for MEDLINE]
Free PMC Article

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