Send to

Choose Destination
Toxicol Ind Health. 2015 Sep;31(9):792-801. doi: 10.1177/0748233713475509. Epub 2013 Feb 1.

Evaluation of genotoxic effects of five flavour enhancers (glutamates) on the root meristem cells of Allium cepa.

Author information

Faculty of Science, Department of Biology, Cumhuriyet University, Sivas, Turkey


The effects of different treatments with flavour enhancers monosodium glutamate, monopotassium glutamate, calcium diglutamate, monoammonium glutamate, and magnesium diglutamate on the cytology, DNA content, and interphase nuclear volume (INV) of A. cepa were investigated. Three concentrations of these additives - 20, 40, and 60 ppm - were applied for 6, 12, and 24 h. All the concentrations of these chemicals showed an inhibitory effect on cell division in root tips of A. cepa and caused a decrease in mitotic index values. Additionally, all the treatments changed the frequency of mitotic phases when compared with the control groups. These compounds increased chromosome abnormalities, among them are micronuclei, c-mitosis, anaphase bridges, stickiness, binucleus, laggards, and breaks. The nuclear DNA content and INV decreased when compared with control groups.


Allium cepa; DNA content; genotoxic effect; interphase nuclear volume; magnesium diglutamate; monoammonium glutamate; monopotassium glutamate; monosodium glutamate

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center