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Transplant Proc. 2013 Jan-Feb;45(1):157-62. doi: 10.1016/j.transproceed.2012.10.019.

B- and T-lymphocyte attenuator/herpes virus entry mediator as early indicators for acute rejection following kidney transplantation.

Author information

1
Department of Kidney Transplantation, Second Hospital of Shandong University, Jinan, People's Republic of China.

Abstract

OBJECTIVE:

The objective of this study was to investigate the roles of B- and T-lymphocyte attenuator (BTLA) and herpes virus entry mediator (HVEM) in acute and chronic transplant rejection and immune tolerance.

METHODS:

The expression patterns of BTLA/HVEM, interleukin (IL)-2, IL-4, IL-10, and interferon (IFN)-γ were analyzed among patients presenting with acute rejection episodes versus those maintaining stable renal function during therapy with mycophenolate mofetil (MMF), cyclosporine, or tacrolimus (FK506) plus prednisolone.

RESULTS:

The expressions of BTLA/HVEM in the rejection group were obviously increased compared with the stable group (P < .05), followed by the elevation of serum levels of IL-2 and IFN-γ.

CONCLUSION:

The expression levels of BTLA/HVEM can be considered to be early indicators of an acute rejection episode following kidney transplantation.

[Indexed for MEDLINE]

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