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Transplant Proc. 2013 Jan-Feb;45(1):157-62. doi: 10.1016/j.transproceed.2012.10.019.

B- and T-lymphocyte attenuator/herpes virus entry mediator as early indicators for acute rejection following kidney transplantation.

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Department of Kidney Transplantation, Second Hospital of Shandong University, Jinan, People's Republic of China.



The objective of this study was to investigate the roles of B- and T-lymphocyte attenuator (BTLA) and herpes virus entry mediator (HVEM) in acute and chronic transplant rejection and immune tolerance.


The expression patterns of BTLA/HVEM, interleukin (IL)-2, IL-4, IL-10, and interferon (IFN)-γ were analyzed among patients presenting with acute rejection episodes versus those maintaining stable renal function during therapy with mycophenolate mofetil (MMF), cyclosporine, or tacrolimus (FK506) plus prednisolone.


The expressions of BTLA/HVEM in the rejection group were obviously increased compared with the stable group (P < .05), followed by the elevation of serum levels of IL-2 and IFN-γ.


The expression levels of BTLA/HVEM can be considered to be early indicators of an acute rejection episode following kidney transplantation.

[Indexed for MEDLINE]

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