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Retrovirology. 2013 Feb 1;10:12. doi: 10.1186/1742-4690-10-12.

M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding.

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1
Department of Biomedical Sciences, Unit of Virology, Institute of Tropical Medicine, Antwerp, B-2000, Belgium.

Abstract

BACKGROUND:

HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen.

FINDINGS:

To address this problem, here, we report that pretreatment of HIV-infected peripheral blood mononuclear cells (PBMCs) with a 27 amino acid CD4-mimetic, M48U1, causes dramatic and prolonged reduction of infectious virus output, due to its induction of gp120 shedding.

CONCLUSIONS:

M48U1 may, therefore, be valuable for prophylaxis of mucosal HIV-1 transmission.

PMID:
23375046
PMCID:
PMC3571899
DOI:
10.1186/1742-4690-10-12
[Indexed for MEDLINE]
Free PMC Article
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