Format

Send to

Choose Destination
Curr Opin Neurobiol. 2013 Aug;23(4):675-83. doi: 10.1016/j.conb.2013.01.003. Epub 2013 Jan 29.

Recent developments in animal models of drug relapse.

Author information

1
Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA. nathan.marchant@nih.gov

Abstract

Drug craving and relapse to drug use during abstinence are defining features of addiction. Evidence indicates that drug craving and relapse in humans are often provoked by acute exposure to the self-administered drug, drug-associated cues, or stress. During the last two decades, this clinical scenario has been primarily studied at the preclinical level using the classical reinstatement model. However, a single preclinical model cannot capture the complicated nature of human drug relapse. Therefore, more recently, we and others have developed several other models to study different facets of human drug relapse. In this review, we introduce and discuss recent findings from these other relapse models, including incubation of drug craving, reacquisition and resurgence models, and punishment-based and conflict-based relapse models.

PMID:
23374536
PMCID:
PMC3644546
DOI:
10.1016/j.conb.2013.01.003
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center