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Cell. 2013 Jan 31;152(3):406-16. doi: 10.1016/j.cell.2013.01.005.

Genomes on the edge: programmed genome instability in ciliates.

Author information

1
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA.

Abstract

Ciliates are an ancient and diverse group of microbial eukaryotes that have emerged as powerful models for RNA-mediated epigenetic inheritance. They possess extensive sets of both tiny and long noncoding RNAs that, together with a suite of proteins that includes transposases, orchestrate a broad cascade of genome rearrangements during somatic nuclear development. This Review emphasizes three important themes: the remarkable role of RNA in shaping genome structure, recent discoveries that unify many deeply diverged ciliate genetic systems, and a surprising evolutionary "sign change" in the role of small RNAs between major species groups.

PMID:
23374338
PMCID:
PMC3725814
DOI:
10.1016/j.cell.2013.01.005
[Indexed for MEDLINE]
Free PMC Article

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