Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell. 2013 Jan 31;152(3):385-6. doi: 10.1016/j.cell.2013.01.025.

Conformational ensembles in GPCR activation.

Author information

1
Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

Abstract

Recent advances in G-protein-coupled receptor structural biology have provided only limited insight into the active conformations of these key signaling molecules. A paper from Nygaard et al. reveals the dynamic nature of GPCRs along the activation pathway by complementing NMR experiments with ultralong-timescale molecular dynamics simulations.

PMID:
23374334
DOI:
10.1016/j.cell.2013.01.025
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center