Format

Send to

Choose Destination
Leuk Lymphoma. 2013 Oct;54(10):2251-4. doi: 10.3109/10428194.2013.772605. Epub 2013 Mar 4.

Association between polymorphisms in PDCD1 gene and aplastic anemia in Chinese Han population.

Author information

1
Department of Pharmacology, College of Pharmaceutical Science, Soochow University , Suzhou , People's Republic of China.

Abstract

Single nucleotide polymorphism (SNP) of programmed cell death 1 (PD-1, encoded by PDCD1) has been reported to be associated with several autoimmune diseases including rheumatoid arthritis (RA), Graves' disease and multiple sclerosis (MS). In order to study the correlation between PD-1 gene polymorphism and aplastic anemia in a Chinese Han population, two SNPs, PD-1.1 G/A (rs36084323) and PD-1.6 G/A (rs10204525), were genotyped in 166 patients with aplastic anemia and 144 healthy controls by direct sequencing. All genotype distributions in both patients and controls were in Hardy-Weinberg equilibrium. Associations of genotypes and alleles with aplastic anemia were analyzed. The results suggested that the G allele of PD-1.1 was associated with an increased risk for aplastic anemia, while SNP of PD-1.6 was not associated with aplastic anemia in a Chinese Han population.

PMID:
23373967
DOI:
10.3109/10428194.2013.772605
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center