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Org Lett. 2013 Feb 15;15(4):878-81. doi: 10.1021/ol400011u. Epub 2013 Feb 1.

Hypochlorous acid turn-on fluorescent probe based on oxidation of diphenyl selenide.

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  • 1Department of Applied Chemistry, National Chiao Tung University, Hsinchu, Taiwan 300, ROC.

Abstract

A BODIPY-based fluorescent probe, HCSe, has been successfully developed for the rapid detection of hypochlorous acid based on the specific HOCl-promoted oxidation of diphenyl selenide in response to the amount of HOCl. Confocal fluorescence microscopy imaging using RAW264.7 cells showed that the new probe HCSe could be used as an effective fluorescent probe for detecting HOCl in living cells.

PMID:
23373559
DOI:
10.1021/ol400011u
[PubMed - indexed for MEDLINE]
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