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Curr Drug Saf. 2012 Nov 1;7(5):375-81.

Prospective evaluation of the dosing regimen of vancomycin in children of different weight categories.

Author information

1
Department of Pediatric Hematology Oncology, Meyer Children’s Hospital, Haifa, Israel.

Abstract

BACKGROUND:

Pharmacokinetics (PK), pharmacodynamics and optimal dosing of vancomycin in obese children is not known. Higher trough levels of vancomycin may improve outcomes. This prospective study evaluated the appropriateness of twice-daily regimen for the adherence to guidelines, among obese and non obese children.

METHODS:

Children receiving vancomycin, (20 mg/kg BID) were included. Patients were divided into 3 groups. Adequacy was defined as trough level ≥ 10mg/L and AUC/MIC > 400. An alternative-dosing regimen was calculated based on individual PK parameters.

RESULTS:

Seventy-seven pairs (trough, peak) were taken from 51 children. Mean trough level was 3.36 ± 2.58, only 3% fell in therapeutic range, no statistical difference was observed between obese, normal weight or underweight groups. One child had an AUC/MIC > 400. All children recovered.

CONCLUSION:

PK properties of all weight groups were similar. More frequent and higher doses are needed to achieve the goals of current guidelines.

PMID:
23373553
[Indexed for MEDLINE]

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