[Proton beam radiotherapy of uveal melanoma--preliminary results]

Klin Oczna. 2012;114(3):173-9.
[Article in Polish]

Abstract

Purpose: Presentation of the proton beam radiotherapy (PBR) as a method of treatment of the uveal melanoma patients in the Department of Ophthalmology and Ocular Oncology and Nuclear Physics Institute in Cracow, Poland and their preliminary results.

Material and methods: Nine patients with only choroidal melanoma were treated using PBR between January and April 2011. There were 4 women (44%) and 5 men (56%), a mean age 56 years (38-72). The mean tumor thickness using ultrasounds was 4.14 mm (1.4-9.6 mm).

Results: The mean follow-up was 6 months (5-7). The mean tumor thickness after PBR was 2.47 mm (0-9.3 mm). In 2 patients endoresection of irradiated tumor mass was performed with final flat scar. After exclusion of these patients from analysis, the mean thickness was 3.17 mm (1.5-9.3 mm). In 6 patients the visual function was stable.

Conclusions: The preliminary results show that PBR is highly precise method of uveal melanoma treatment achieving high rates of local control. This method necessitates a close co-operation between ophthalmologist, oncologist, radiotherapists, and medical physicist as well as an elaboration of own procedures of planning and treatment. uveal melanoma, radiotherapy, proton-beam radiotherapy.

MeSH terms

  • Adult
  • Aged
  • Combined Modality Therapy
  • Disease-Free Survival
  • Eye Enucleation
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Melanoma / radiotherapy*
  • Melanoma / surgery
  • Middle Aged
  • Proton Therapy
  • Radiotherapy, High-Energy / methods*
  • Treatment Outcome
  • Uveal Neoplasms / radiotherapy*
  • Uveal Neoplasms / surgery
  • Visual Acuity

Substances

  • Protons

Supplementary concepts

  • Uveal melanoma