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Circ Res. 2013 Feb 1;112(3):e25-8. doi: 10.1161/CIRCRESAHA.111.300197.

Thymosin β4 is not required for embryonic viability or vascular development.

Author information

1
Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.

Abstract

RATIONALE:

Rossdeutsch et al describe a requirement for thymosin β4 (Tβ4) in vascular development. Impaired mural cell migration, differentiation, partial embryonic lethality, and hemorrhaging were observed after analysis of 2 lines of mice, one of which was germline null for Tβ4 and another in which Tβ4 was knocked down by endothelial-specific expression of Tβ4 short hairpin RNA. These data are in direct contrast to our published global and cardiac-specific Tβ4-knockout lines. Thus, the role of Tβ4 needs to be clarified to understand its importance in cardiovascular development.

OBJECTIVE:

To investigate and clarify the role of Tβ4 in vascular smooth muscle cell development and vessel stability.

METHODS AND RESULTS:

Examination of Tβ4 global knockouts did not demonstrate embryonic hemorrhaging, altered mural cell development, or lethality. Endothelial-specific knockouts also did not exhibit any embryonic lethality and were viable to adulthood.

CONCLUSIONS:

Analysis of our Tβ4 global and cardiac- and endothelial-specific knockout models demonstrated that Tβ4 is dispensable for embryonic viability and vascular development.

PMID:
23371905
PMCID:
PMC3712119
DOI:
10.1161/CIRCRESAHA.111.300197
[Indexed for MEDLINE]
Free PMC Article

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