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Circ Res. 2013 Feb 1;112(3):534-48. doi: 10.1161/CIRCRESAHA.111.250266.

Induced pluripotent stem cells in cardiovascular drug discovery.

Author information

1
Muscle Development and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA. mmercola@sanfordburnham.org

Abstract

The unexpected discovery that somatic cells can be reprogrammed to a pluripotent state yielding induced pluripotent stem cells has made it possible to produce cardiovascular cells exhibiting inherited traits and disorders. Use of these cells in high throughput analyses should broaden our insight into fundamental disease mechanisms and provide many benefits for patients, including new therapeutics and individually tailored therapies. Here we review recent progress in generating induced pluripotent stem cell-based models of cardiovascular disease and their multiple applications in drug development.

PMID:
23371902
PMCID:
PMC3706265
DOI:
10.1161/CIRCRESAHA.111.250266
[Indexed for MEDLINE]
Free PMC Article

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