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J Mater Sci Mater Med. 2013 Apr;24(4):1113-22. doi: 10.1007/s10856-013-4872-y. Epub 2013 Jan 31.

Materials characterization and histological analysis of explanted polypropylene, PTFE, and PET hernia meshes from an individual patient.

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Department of Biological Engineering, University of Missouri-Columbia, Columbia, MO 65211, USA.


During its tenure in vivo, synthetic mesh materials are exposed to foreign body responses, which can alter physicochemical properties of the material. Three different synthetic meshes comprised of polypropylene, expanded polytetrafluoroethylene (ePTFE), and polyethylene terephthalate (PET) materials were explanted from a single patient providing an opportunity to compare physicochemical changes between three different mesh materials in the same host. Results from infrared spectroscopy demonstrated significant oxidation in polypropylene mesh while ePTFE and PET showed slight chemical changes that may be caused by adherent scar tissue. Differential scanning calorimetry results showed a significant decrease in the heat of enthalpy and melt temperature in the polypropylene mesh while the ePTFE and PET showed little change. The presence of giant cells and plasma cells surrounding the ePTFE and PET were indicative of an active foreign body response. Scanning electron micrographs and photo micrographs displayed tissue entrapment and distortion of all three mesh materials.

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