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Cancer Lett. 2013 Jun 10;333(2):222-8. doi: 10.1016/j.canlet.2013.01.036. Epub 2013 Jan 28.

The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer.

Author information

1
Dept. of Statistics, TU Dortmund University, Dortmund, Germany.

Abstract

A prognostic impact of immunoglobulin kappa C (IGKC) expression has been described in cancer. We analysed the influence of B-cell and plasma cell markers, as well as IGKC expression, in non-small lung cancer (NSCLC) using immunohistochemistry on a tissue microarray. IGKC protein expression was independently associated with longer survival, with particular impact in the adenocarcinoma subgroup. Moreover, a correlation was seen with CD138+ cells, but not with CD20. CD138 expression revealed a comparable association with survival. In conclusion, IGKC expression in stroma-infiltrating plasma cells is a prognostic marker in NSCLC, supporting emerging treatment concepts that exploit the humoral immune response.

PMID:
23370224
DOI:
10.1016/j.canlet.2013.01.036
[Indexed for MEDLINE]

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