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Behav Brain Res. 2013 Apr 15;243:273-7. doi: 10.1016/j.bbr.2013.01.021. Epub 2013 Jan 29.

Ethanol-induced conditioned partner preference in female mice.

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1
Department of Cell and Neurobiology, Keck School of Medicine at the University of Southern California, Los Angeles, CA 90033, United States. riw@usc.edu

Abstract

Drinking behavior and social context are intimately intertwined. Peer relations can promote drinking. Conversely, alcohol promotes social interaction. The present study tested female mice for ethanol-induced conditioned partner preference. Ovariectomized (OVX) C57Bl/6 females with chronic estradiol replacement (OVX+E) received saline or ethanol (1, 2 or 4 g/kg) ip and were paired 4 × for 30 min each with 1 of 2 stimulus females. The test female was paired with the CS- stimulus female following saline, and was paired with the CS+ female following ethanol. After pairing, we measured proximity of the test female to the CS+ and CS- females in a 10' test. In a second study, OVX and OVX+E females were tested for conditioned partner preference (CS+ vs. CS-) in response to 2.5 g/kg ethanol. In separate groups of mice, both test and stimulus females (IS+) received ethanol during pairing to determine if test mice develop conditioned partner preference for another intoxicated mouse. OVX+E test females showed conditioned partner preference for the CS+ female in response to ethanol at 2g/kg (change in preference score for CS+: +86.6 ± 30.0 s/10 min), but not at 0, 1 or 4 g/kg. At 2.5 g/kg ethanol, OVX+E females developed conditioned partner preference for either IS+ (+63.6 ± 24.0 s) or CS+ females (+93.8 ± 27.1 s). OVX test females demonstrated ethanol-induced conditioned partner preference only for the IS+ female (+153.8 ± 32.0 s). These data demonstrate that ethanol promotes social preference in female mice, and that estradiol enhances this effect.

PMID:
23369716
PMCID:
PMC3593977
DOI:
10.1016/j.bbr.2013.01.021
[Indexed for MEDLINE]
Free PMC Article
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