Epidemiology and trend of neurological diseases associated to HIV/AIDS. Experience of Mexican patients 1995-2009

Clin Neurol Neurosurg. 2013 Aug;115(8):1322-5. doi: 10.1016/j.clineuro.2012.12.018. Epub 2013 Jan 29.

Abstract

Objective: The aim of this study was to identify the main neurological conditions associated with HIV/AIDS in Mexican patients treated at the National Institute of Neurology and Neurosurgery (NINN) in Mexico city, the main referral center for patients with disorders of the central and peripheral nervous system.

Methods: An observational, transversal and descriptive analysis was performed. We reviewed the databases from the Department of Epidemiology and the medical records of patients with AIDS seen during the period from January 1st, 1995 to December 31, 2009.

Results: 320 patients were detected, the main conditions related to HIV/AIDS were brain toxoplasmosis (42%), cerebral criptoccocosis (28%), tuberculous meningitis (8.7%), linfoma no Hodking (3.75%), acute HIV infection (3.4%) and AIDS dementia complex (3%). No specific trend on morbility and mortality were detected during the period of study.

Conclusions: In Mexico the most common neurological complications of HIV/AIDS are opportunistic infections.

Keywords: Brain toxoplasmosis; Epidemiology; HIV/AIDS; Meningeal cryptococcosis; Mexico; Neurological disease; Trends.

MeSH terms

  • AIDS Dementia Complex / epidemiology
  • AIDS-Related Opportunistic Infections / complications
  • AIDS-Related Opportunistic Infections / epidemiology
  • Acquired Immunodeficiency Syndrome
  • Adolescent
  • Adult
  • Aged
  • Biopsy
  • Cranial Nerve Diseases / epidemiology
  • Cranial Nerve Diseases / etiology
  • Educational Status
  • Employment
  • Female
  • HIV Infections / complications*
  • HIV Infections / epidemiology*
  • HIV Infections / mortality
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Mexico / epidemiology
  • Middle Aged
  • Nervous System Diseases / epidemiology*
  • Nervous System Diseases / etiology*
  • Peripheral Nervous System Diseases / epidemiology
  • Peripheral Nervous System Diseases / etiology
  • Sex Factors
  • Socioeconomic Factors
  • Tomography, X-Ray Computed
  • Toxoplasmosis, Cerebral / epidemiology
  • Toxoplasmosis, Cerebral / etiology
  • Young Adult