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Org Lett. 2013 Feb 15;15(4):780-3. doi: 10.1021/ol303435y. Epub 2013 Jan 31.

Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi.

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1
Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90066, United States.

Abstract

Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylated anthracenone. 3 exhibits T-cell antiproliferative activity with an IC(50) of 3 μM, suggestive of a physiological role as an immunosuppressive agent.

PMID:
23368997
PMCID:
PMC3576815
DOI:
10.1021/ol303435y
[Indexed for MEDLINE]
Free PMC Article
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