Abstract
Main pharmacovigilance updates in 2012 are reviewed here. Dabigatran: elderly patients with renal failure are at higher risk of bleeding. Dual renin-angiotensin-aldosterone system blockade comprising aliskiren is harmful. Incretins: low risk of acute pancreatitis. Interaction between fusidic acid and statins: many reports of rhabdomyolysis. Interactions between boceprevir/telaprevir and antiretroviral therapies: complex, but manageable. Citalopram, ondansetron: maximum recommended doses are reduced. Atomoxetine: significant increase in blood pressure and heart rate in a fraction of exposed patients. Agomelatine: elevated liver enzymes are common. Fingolimod: bradycardia and heart blocks after first dose - stronger safety recommendations regarding use in patients with heart conditions and strengthened cardiovascular monitoring.
MeSH terms
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Adrenergic Uptake Inhibitors / adverse effects
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Adrenergic Uptake Inhibitors / therapeutic use
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Age Factors
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Aged
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Amides / adverse effects
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Amides / therapeutic use
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Antihypertensive Agents / adverse effects
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Antihypertensive Agents / therapeutic use
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Atomoxetine Hydrochloride
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Benzimidazoles / adverse effects
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Benzimidazoles / therapeutic use
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Cardiovascular Diseases / chemically induced
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Cardiovascular Diseases / epidemiology
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Cardiovascular Diseases / etiology
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Dabigatran
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Drug-Related Side Effects and Adverse Reactions / epidemiology
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Drug-Related Side Effects and Adverse Reactions / etiology
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Fibrinolytic Agents / adverse effects
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Fibrinolytic Agents / therapeutic use
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Fumarates / adverse effects
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Fumarates / therapeutic use
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Hemorrhage / chemically induced
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Hemorrhage / epidemiology
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Humans
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Pharmacovigilance*
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Propylamines / adverse effects
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Propylamines / therapeutic use
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beta-Alanine / adverse effects
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beta-Alanine / analogs & derivatives
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beta-Alanine / therapeutic use
Substances
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Adrenergic Uptake Inhibitors
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Amides
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Antihypertensive Agents
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Benzimidazoles
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Fibrinolytic Agents
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Fumarates
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Propylamines
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beta-Alanine
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aliskiren
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Atomoxetine Hydrochloride
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Dabigatran