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Conf Proc IEEE Eng Med Biol Soc. 2012;2012:2068-71. doi: 10.1109/EMBC.2012.6346366.

Intradermal needle-free powdered drug injection by a helium-powered device.

Author information

1
Bioinstrumentation Laboratory, Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. johnhliu@mit.edu

Abstract

We present a new method for needle-free powdered drug injection via a bench-top gas-powered device. This injector provides an alternative method of vaccine delivery to address the cold chain problem--the cost and risk of transporting temperature sensitive vaccines to developing countries. The device houses interchangeable nozzle inserts to vary orifice geometries and is capable of delivering polymer beads (1-5 ┬Ám diameter) into the dermal layer of porcine tissue. Results for injection shape and injection depth versus nozzle orifice diameter demonstrate the device's controllability.

PMID:
23366327
DOI:
10.1109/EMBC.2012.6346366
[Indexed for MEDLINE]

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