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Comput Math Methods Med. 2012;2012:473572. doi: 10.1155/2012/473572. Epub 2012 Dec 19.

Assessing the effects of estrogen on the dynamics of breast cancer.

Author information

1
Department of Applied Mathematics, National University of Science and Technology, Ascot, Bulawayo, Zimbabwe. chipmuf@gmail.com

Abstract

Worldwide, breast cancer has become the second most common cancer in women. The disease has currently been named the most deadly cancer in women but little is known on what causes the disease. We present the effects of estrogen as a risk factor on the dynamics of breast cancer. We develop a deterministic mathematical model showing general dynamics of breast cancer with immune response. This is a four-population model that includes tumor cells, host cells, immune cells, and estrogen. The effects of estrogen are then incorporated in the model. The results show that the presence of extra estrogen increases the risk of developing breast cancer.

PMID:
23365616
PMCID:
PMC3536317
DOI:
10.1155/2012/473572
[Indexed for MEDLINE]
Free PMC Article
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