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Planta Med. 2013 Mar;79(3-4):207-13. doi: 10.1055/s-0032-1328201. Epub 2013 Jan 30.

Anti-inflammatory activity of Bromelia hieronymi: comparison with bromelain.

Author information

1
Laboratory of Plant Proteins, Faculty of Exact Sciences, National University of La Plata, La Plata, Argentina. meerrasti@biol.unlp.edu.ar

Abstract

Some plant proteases (e. g., papain, bromelain, ficin) have been used as anti-inflammatory agents for some years, and especially bromelain is still being used as alternative and/or complementary therapy to glucocorticoids, nonsteroidal antirheumatics, and immunomodulators. Bromelain is an extract rich in cysteine endopeptidases obtained from Ananas comosus. In this study the anti-inflammatory action of a partially purified extract of Bromelia hieronymi fruits, whose main components are cysteine endopeptidases, is presented. Different doses of a partially purified extract of B. hieronymi were assayed on carrageenan-induced and serotonine-induced rat paw edema, as well as in cotton pellet granuloma model. Doses with equal proteolytic activity of the partially purified extract and bromelain showed significantly similar anti-inflammatory responses. Treatment of the partially purified extract and bromelain with E-64 provoked loss of anti-inflammatory activity on carrageenan-induced paw edema, a fact which is consistent with the hypothesis that the proteolytic activity would be responsible for the anti-inflammatory action.

PMID:
23364884
DOI:
10.1055/s-0032-1328201
[Indexed for MEDLINE]

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