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Kidney Int. 2013 Feb;83(2):198-200. doi: 10.1038/ki.2012.415.

Shining light on vitamin D trials in chronic kidney disease.

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1
Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

Abstract

Vitamin D compounds may have extraskeletal functions. Chronic kidney disease (CKD) offers an opportunity to investigate these actions, as vitamin D deficiency is prevalent in this population and actions of vitamin D such as those on the heart and glucose metabolism are highly relevant. However, recent randomized controlled trials have tempered enthusiasm. We appraise a trial by de Boer et al. that addresses effects of paricalcitol on glucose metabolism in CKD, and offer perspectives on future trials.

PMID:
23364588
PMCID:
PMC3991009
DOI:
10.1038/ki.2012.415
[Indexed for MEDLINE]
Free PMC Article
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