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Kidney Int. 2013 Feb;83(2):189-91. doi: 10.1038/ki.2012.418.

Prediction of renal end points in chronic kidney disease.

Author information

1
Division of Nephrology, Department of Medicine, Veterans Affairs Saint Louis Health Care System, Saint Louis, Missouri 63106, USA. zalaly@gmail.com

Abstract

Estimated glomerular filtration rate and albuminuria are dominant clinical predictors of renal outcomes in chronic kidney disease. Wong and collaborators report that BMP-7 and transforming growth factor-β1 improve risk discrimination for renal end points in type 2 diabetes. However, to develop predictive models, clearly defined, clinically meaningful, validated end points must be used. End-stage renal disease and kidney transplantation remain the most definitive renal end points, whereas doubling of serum creatinine and death from renal disease lack rigor.

PMID:
23364584
DOI:
10.1038/ki.2012.418
[Indexed for MEDLINE]
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