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J Cutan Med Surg. 2013 Jan-Feb;17(1):6-12.

Phototherapy in psoriasis: a review of mechanisms of action.

Author information

1
Department of Dermatology, University of California, San Francisco, CA, USA.

Abstract

BACKGROUND:

Phototherapy is one of the most efficacious treatment options for psoriasis. New, emerging studies are beginning to define the biologic mechanisms by which phototherapy improves psoriasis.

METHODS:

To provide an overview of the mechanisms thought to be responsible for the therapeutic effects of phototherapy, a review was performed on all relevant published studies in the Medline database from January 1, 1985, to August 15, 2011.

FINDINGS:

Four categories of action were proposed in the literature to describe the effects of phototherapy in psoriasis: (1) alteration of the cytokine profile, (2) induction of apoptosis, (3) promotion of immunosuppression, and (4) all other mechanisms.

CONCLUSIONS:

Phototherapy acts through a combination of pathways to confer therapeutic benefits in psoriasis, and these different modalities may help explain its particular usefulness in treating this cutaneous disease.

PMID:
23364144
PMCID:
PMC3736829
DOI:
10.2310/7750.2012.11124
[Indexed for MEDLINE]
Free PMC Article

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