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Zhonghua Xin Xue Guan Bing Za Zhi. 2012 Dec;40(12):1024-9.

[Association between genetic polymorphism of the six-transmembrane protein of prostate 2 and obesity in Uygur].

[Article in Chinese]

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1
Xinjiang Medical University, Urumqi 830054, China.

Abstract

OBJECTIVE:

To investigate the association between genetic variations of the six transmembrane protein of prostate 2 (STAMP2) and obesity in Xinjiang Uygur population.

METHODS:

A total of 2332 Uygur subjects (1455 obesity and 877 non-obesity control subjects) were included in this case-control study based on epidemiological survey. Genetic variations of STAMP2 gene functional region were sequenced. The representative variations selected were genotyped by TaqMan-PCR method.

RESULTS:

Twenty genetic variations, including 14 novel variations, were identified. The genotype distributions of the control group and obesity group were in the Hardy-Weinberg equilibrium (both P > 0.05). The frequency of AA of rs1981529 (67.6% vs. 62.8%, P < 0.05) and the frequency of G-A-G haplotype (62.4% vs. 58.9%, P < 0.05) in obesity group were significantly higher than that in controls while the frequency of A-G-G haplotype was significantly lower in the obesity patients than that in the control group (17% vs. 20%, P < 0.05). After adjusting age, sex, smoking and drinking, logistic regression analysis showed that the AA genotype of rs1981529 (OR: 1.276, 95%CI: 1.049 - 1.552; P < 0.05) and the G-A-G haplotype (OR: 1.356, 95%CI: 1.007 - 1.862, P < 0.05) were the independent risk factors for obesity in this cohort.

CONCLUSION:

The AA genotype of rs1981529 and G-A-G haplotype are associated with obesity in Uygur population of Xinjiang.

PMID:
23363718
[Indexed for MEDLINE]
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